Syntheses of Coniine, DAB-1, and Nectrisine

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Our work on the total syntheses of the alkaloid natural products (–)-coniine, DAB-1, and nectrisine just appeared in ACS Omega! This was collaborative work with Prof. Deardorff to develop a robust synthesis of these biologically active natural products. The approach utilizes an enzyme-catalyzed hydrocyanation to establish the key stereochemistry, which is followed by transition metal-catalyzed reactions to transform this building block into the natural products. We envision this approach as a general platform for the enantioselective syntheses of alkaloid natural products. Congrats to the undergraduates that worked on this project together!

2019 Summer Research Conference

Another summer, another URC conference in the books! We had a fantastic ten weeks of summer, and we are definitely not ready to part with our beloved former members, Anne Marie and Daniel, who stayed for their final summer in the Cannon Lab. Anne Marie is off to Harvard and Daniel is off to UC Irvine, where they will both continue to do amazing work. We wish them the best of luck in graduate school!

Cannon Lab at NOS 2019

Kayla, Marc, and Yuri had a great time presenting their research this week at the 46th National Organic Symposium at Indiana University, and Yuri was awarded the Undergraduate Poster Prize for her session! Jeff was also featured on a panel about academic careers at PUIs and had the opportunity to speak about his experience leading a group of undergrads. See you in two years for even more exciting chemistry, NOS!